Skip to Top navigation
Skip to Content

International Gene Clinic

 
 

International Gene Clinic - 0845 410 4100

Prader-Willi Syndrome

Prader-Willi Syndrome

Prader-Willi syndrome (PWS) is the most recognised form of inherited childhood obesity.     

Epidemiology

  • Incidence: 1 in 10 000-15 000
  • All ethnic groups
  • Male = Female

Clinical Presentation

Clinical features are variable

  • Breech presentation in utero
  • Feeding problems in infancy
  • Failure to thrive initially
  • Hyperphagia
  • Truncal obesity
  • Morbid obesity developing between ages 1-6 years

back to top^

 

Physical Signs

  • Almond-shaped palpebral fissures
  • Down-turned corners of the mouth
  • Small hands and feet.
  • Hypotonia
  • Microcephaly
  • Hypogonadotrophic hypogonadism (males and females)
  • Mental disability (IQ evenly distributed around 60 mark).
  • Short  stature
  • Dental malocclusion (40%)
  • Cryptorchidism (80%)
  • Labial hypoplasia
  • Micropenis
  • Strabismus (40-95%)

back to top^

Complications

  • Fertility is rare in men and un-common in women.
  • Day time sleepiness is common (50-90%)
  • Respiratory problems and sleep apnoea requiring anaesthetic precautions
  • Congestive heart failure due to morbid obesity
  • Diabetes mellitus (15%)
  • Older children and adults are often depressed

back to top^

Make Enquiry

Spam Authentication *
13 + 13=

(Authentication Tool to Prevent Spam)



The Information on this site is for information only, and is not meant to substitute the advice of your own physician or other medical professional.
  Copyright 2011 International Gene Clinic      Contact Us   Links   Disclaimer   Terms & Conditions       Professional Healthcare Websites